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MYP_161594
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Basic Information
Piscidin-1 (Pis-1; Piscidin 1; fish, chordates, animals)
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiviral
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor cross
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
22 amino acids
C122H187N37O25
Standard
Sequence
FFHHIFRGIVHVGKTIHRLVTG
Physicochemical Analysis
2572.02 Da
12.00
3.11
2.70
0.1413
0.45
0.73
0.24
8.11
110.45
0.1364
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
979.42
-5.37
36.0
32.0
82.0
184.0
7.0
21.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0088319 VERIFIED: YES
Provenance & Taxonomy
Morone saxatilis [Animal]
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
epidermitis
5-10 μM
MIC
PMID11713517 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11713517/
RECORD: Rec_0089150 VERIFIED: YES
Provenance & Taxonomy
Morone saxatilis [Animal]
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
mitis
1.25-2.5 μM
MIC
PMID11713517 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11713517/
RECORD: Rec_0090004 VERIFIED: YES
Provenance & Taxonomy
Morone saxatilis [Animal]
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Klebsiella pneumoniae
2.5-5 μM
MIC
PMID11713517 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11713517/
RECORD: Rec_0099277 VERIFIED: YES
Provenance & Taxonomy
Morone saxatilis × Morone chrysops [Animal]
Piscidin
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Anticancer
Breast cancer (cell line not reported)
PaperCancerPPD2 curated year-page record; primary PMID 11713517 (2001), additional curated PMID 18957441. PMID11713517;18957441 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11713517/
RECORD: Rec_0104739 VERIFIED: YES
Provenance & Taxonomy
Morone saxatilis [Animal]
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
fumigatus
50-100 μM
MIC
PMID11713517 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11713517/
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