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MYP_161594
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Basic Information
Piscidin-1 (Pis-1; Piscidin 1; fish, chordates, animals)
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiviral
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor cross
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
22 amino acids
C122H187N37O25
Standard
Sequence
FFHHIFRGIVHVGKTIHRLVTG
Physicochemical Analysis
2572.02 Da
12.00
3.11
2.70
0.1413
0.45
0.73
0.24
8.11
110.45
0.1364
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
979.42
-5.37
36.0
32.0
82.0
184.0
7.0
21.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0417189 VERIFIED: YES
Provenance & Taxonomy
Morone saxatilis [Animal]
Piscidin
34816
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-CCV Entry inhibition
Channel Catfish virus (CCV)
4 μM
% inhibition
Mammalian: 1.1 h; Yeast: 3 min; E. coli: 2 min
PaperInactivation of viruses infecting ectothermic animals by amphibian and piscine antimicrobial peptides. | Chinchar VG, Bryan L, Silphadaung U, Noga E, Wade D, Rollins-Smith L. | Virology. 2004 Jun 1;323(2):268-75. | DOI:10.1016/j.virol.2004.02.029 | PMID:15193922 PMID15193922 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15193922/
RECORD: Rec_0422398 VERIFIED: YES
Provenance & Taxonomy
Morone chrysops x Morone saxatilis [Animal]
Pleurocidin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hemolytic
human red blood cells
100 μg/mL
Hemolysis
PMID31354312;30021422 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31354312/
RECORD: Rec_0425226 VERIFIED: YES
Provenance & Taxonomy
Morone saxatilis [Animal]
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Enterococcus faecalis VRE
5-10 μM
MIC
PMID11713517 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11713517/
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