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MYP_161594
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Basic Information
Piscidin-1 (Pis-1; Piscidin 1; fish, chordates, animals)
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiviral
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor cross
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
22 amino acids
C122H187N37O25
Standard
Sequence
FFHHIFRGIVHVGKTIHRLVTG
Physicochemical Analysis
2572.02 Da
12.00
3.11
2.70
0.1413
0.45
0.73
0.24
8.11
110.45
0.1364
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
979.42
-5.37
36.0
32.0
82.0
184.0
7.0
21.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0397814 VERIFIED: YES
Provenance & Taxonomy
Morone saxatilis [Animal]
Piscidin
34816
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-FV3 Entry inhibition
Frog Virus 3 (FV3)
13 μM
% inhibition
Mammalian: 1.1 h; Yeast: 3 min; E. coli: 2 min
PaperInactivation of viruses infecting ectothermic animals by amphibian and piscine antimicrobial peptides. | Chinchar VG, Bryan L, Silphadaung U, Noga E, Wade D, Rollins-Smith L. | Virology. 2004 Jun 1;323(2):268-75. | DOI:10.1016/j.virol.2004.02.029 | PMID:15193922 PMID15193922 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15193922/
RECORD: Rec_0397915 VERIFIED: YES
Provenance & Taxonomy
Morone saxatilis [Animal]
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Micrococcus luteus
10-20 μM
MIC
PMID11713517 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11713517/
RECORD: Rec_0400842 VERIFIED: YES
Provenance & Taxonomy
Morone saxatilis [Animal]
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Shigella flexneri
2.5-5 μM
MIC
PMID11713517 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11713517/
RECORD: Rec_0412050 VERIFIED: YES
Provenance & Taxonomy
Morone chrysops x Morone saxatilis [Animal]
Piscidin
45352
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Not included yet
Amidation
Bio-Activity Profile
Antimicrobial Anticancer
SKOV-3
MTT assay
PaperPiscidin-1 Induces Apoptosis via Mitochondrial Reactive Oxygen Species-Regulated Mitochondrial Dysfunction in Human Osteosarcoma Cells PMID32193508 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32193508/
RECORD: Rec_0414895 VERIFIED: YES
Provenance & Taxonomy
Morone saxatilis [Animal]
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Neurospora crassa
1.56-3.12 μM
MIC
PMID11713517 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11713517/
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