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MYP_161594
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Basic Information
Piscidin-1 (Pis-1; Piscidin 1; fish, chordates, animals)
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiviral
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor cross
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
22 amino acids
C122H187N37O25
Standard
Sequence
FFHHIFRGIVHVGKTIHRLVTG
Physicochemical Analysis
2572.02 Da
12.00
3.11
2.70
0.1413
0.45
0.73
0.24
8.11
110.45
0.1364
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
979.42
-5.37
36.0
32.0
82.0
184.0
7.0
21.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0293085 VERIFIED: YES
Provenance & Taxonomy
Morone saxatilis [Animal]
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Serratia marcescens
20 μM
MIC
PMID11713517 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11713517/
RECORD: Rec_0308101 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Piscidin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antifungal
Human erythrocytes
3.125 μM
Hemolysis
Paperhttps://pubmed.ncbi.nlm.nih.gov/18827353/ PMID18827353 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18827353/
RECORD: Rec_0315358 VERIFIED: YES
Provenance & Taxonomy
Morone saxatilis [Animal]
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
tropacalis
10-20 μM
MIC
PMID11713517 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11713517/
RECORD: Rec_0315693 VERIFIED: YES
Provenance & Taxonomy
Morone chrysops x Morone saxatilis [Animal]
Pleurocidin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antiviral Anti-Gram-positive Anti-Gram-negative
Clinical strain of methicillin resistant Staphylococcus aureus
3.1 μg/mL
MIC
PMID31354312;30021422 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31354312/
RECORD: Rec_0319606 VERIFIED: YES
Provenance & Taxonomy
Morone saxatilis [Animal]
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Aerogenes
10-20 μM
MIC
PMID11713517 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11713517/
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