Peptide Database

Peptide Name[D-Pro4,D-Trp7,9,10]substance P (4-11)

Function Ontology

Neurological / Signaling ▸ Neuropeptide activity

Neurological / Signaling ▸ Receptor modulation ▸ Agonist

Neurological / Signaling ▸ Receptor modulation ▸ Antagonist

Neurological / Signaling ▸ Signaling peptide

Standard StatusStandard

Sequence Length8 amino acids

Chemical FormulaC62H73N13O11S

DescriptionStandard

        PQQWFWWM
    

Molecular Weight1208.39 Da

Isoelectric Point (pI)5.96

Net Charge (pH 7.0)-0.04

Net Charge (pH 7.4) -0.10

Charge Density (pH 7.0) -0.0052

GRAVY Index-0.82

Hydrophobic Moment 0.27

Boman Index0.34

Instability Index86.50

Aliphatic Index 0.00

Aromaticity 0.5000

Extinction Coeff. Reduced 16500.00

Extinction Coeff. Oxidized 16500.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 386.58

LogP 1.92

H-bond Donors 14.0

H-bond Acceptors 12.0

Rotatable Bonds 32.0

Heavy Atoms 87.0

Ring Count 8.0

Amide Bonds 9.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0243485 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

FamilyGtoPdb peptide ligand

Structure & Mods

Configsynthetic linear peptide [Linear]

Chiralitynoncanonical stereochemical modification [Modified]

Bio-Activity Profile

Function

Receptor antagonist Neuropeptide activity Signaling peptide

TargetBB2 receptor (Rat); BB2 receptor (Human)

Activity>10000 nM

MethodKi