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MYP_161424
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Basic Information
E1P43-2
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition
Standard
18 amino acids
C116H163N27O29
Standard
Sequence
RWTEQLASNYWILEYLWK
Physicochemical Analysis
2399.70 Da
6.14
-0.24
-0.45
-0.0132
-0.64
0.47
0.04
72.41
92.22
0.2778
19480.00
19480.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
935.01
-2.45
34.0
29.0
74.0
172.0
8.0
19.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0146809 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Aurein
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
HIV-1 NL4-3
19.7±9.1 μM
IC50
PMID26905802 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26905802/
RECORD: Rec_0259261 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-HIV-1 Fusion inhibition
HIV-1 NL4-3 | TZM-bl cells
19.7±9.1 μM
IC50
Mammalian: 1 h; Yeast: 2 min; E. coli: 2 min
PaperDefinition of an 18-mer Synthetic Peptide Derived from the GB virus C E1 Protein as a New HIV-1 Entry Inhibitor. | Gómara MJ, Sánchez-Merino V, Paús A, Merino-Mansilla A, Gatell JM, Yuste E, Haro I. | Biochim Biophys Acta. 2016 Jun;1860(6):1139-48. | DOI:10.1016/j.bbagen.2016.02.008 | PMID:26905802 PMID26905802 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26905802/
RECORD: Rec_0397368 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
Virus:HIV-1 NL4-3:inhibition of virus infection in TZM-bl cells
19.7±9.1 μM
IC50
PMID26905802 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26905802/