Peptide Database

Peptide NameSpiderine-1b (M-oxotoxin-Ot3b) (M-OXTX-Ot3b) (OtTx1b)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Insecticidal/Pest control ▸ Insecticidal activity

Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Toxin

Standard StatusStandard

Sequence Length166 amino acids

Chemical FormulaC812H1286N216O246S12

DescriptionStandard

        MKFALVLLGICAFYLVNATGDLETELEASELQELQEALDLIGETSLESLEAEELEEARKFKWGKLFSAAKKLYKKGKKLSKNKNFKKALKFGKQLAKNLQAGEEHEPGTPVGNNKCWAIGTTCSDDCDCCPEHHCHCPAGKWLPGLFRCTCQVTESDKVNKCPPAE
    

Molecular Weight18394.98 Da

Isoelectric Point (pI)6.13

Net Charge (pH 7.0)-2.22

Net Charge (pH 7.4) -2.87

Charge Density (pH 7.0) -0.0134

GRAVY Index-0.45

Hydrophobic Moment 0.72

Boman Index-0.04

Instability Index40.08

Aliphatic Index 74.16

Aromaticity 0.0723

Extinction Coeff. Reduced 19480.00

Extinction Coeff. Oxidized 20105.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 7429.09

LogP -70.23

H-bond Donors 259.0

H-bond Acceptors 260.0

Rotatable Bonds 628.0

Heavy Atoms 1286.0

Ring Count 26.0

Amide Bonds 177.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0349582 VERIFIED: YES

Provenance & Taxonomy

OrganismOxyopes takobius [Animal]

FamilySpiderine; Cationic spiderine subfamily

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Cytolytic Toxin Cytotoxic Insecticidal Non-hemolytic