Peptide Database

Peptide NameInsulin-like growth factor II

Function Ontology

Anticancer

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Cardiovascular

Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory

Hormonal / Endocrine ▸ Hormone peptide

Metabolic

Regulatory peptide ▸ Biological modulation

Regulatory peptide ▸ Biological regulation

Reproductive biology ▸ Reproductive modulation

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length67 amino acids

Chemical FormulaC321H504N94O103S6

DescriptionStandard

        AYRPSETLCGGELVDTLQFVCSDRGFYFSRPSSRANRRSRGIVEECCFRSCDLALLETYCATPAKSE
    

Molecular Weight7520.39 Da

Isoelectric Point (pI)6.46

Net Charge (pH 7.0)-0.24

Net Charge (pH 7.4) -0.54

Charge Density (pH 7.0) -0.0036

GRAVY Index-0.34

Hydrophobic Moment 0.77

Boman Index-0.13

Instability Index78.42

Aliphatic Index 61.19

Aromaticity 0.1045

Extinction Coeff. Reduced 4470.00

Extinction Coeff. Oxidized 4845.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 3204.10

LogP -38.33

H-bond Donors 122.0

H-bond Acceptors 109.0

Rotatable Bonds 244.0

Heavy Atoms 524.0

Ring Count 10.0

Amide Bonds 68.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0094000 VERIFIED: YES

Provenance & Taxonomy

OrganismRattus norvegicus [Animal]

FamilyInsulin-like growth factor

Tax ID10116

Structure & Mods

Configdisulfide-constrained peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide9-47; 21-60; 46-51

Bio-Activity Profile

Function

Anticancer Cytotoxic Hormone Endocrine Cardiovascular Metabolic regulation Physiological regulation Reproductive regulator Growth regulation Development regulation Receptor modulation ACE inhibitory

Targetglucose metabolism in adipose tissue

Half-LifeMammalian: 4.4 hour; Yeast: >20 hour; E. coli: >10 hour

RECORD: Rec_0142018 VERIFIED: YES

Provenance & Taxonomy

OrganismRattus norvegicus [Animal]

FamilyInsulin

Tax ID10116

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Hormone Metabolic

RECORD: Rec_0153250 VERIFIED: YES

Provenance & Taxonomy

OrganismRattus norvegicus [Animal]

FamilyInsulin-like growth factor

Tax ID10116

Structure & Mods

Configdisulfide-constrained peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide9-47; 21-60; 46-51

Bio-Activity Profile

Function

Anticancer Cytotoxic Hormone Endocrine Cardiovascular Metabolic regulation Physiological regulation Reproductive regulator Growth regulation Development regulation Receptor modulation ACE inhibitory

Half-LifeMammalian: 4.4 hour; Yeast: >20 hour; E. coli: >10 hour