Peptide Database

Peptide NameSecapin (AcSecapin-1)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antibiotic activity

Antimicrobial ▸ Antifungal

Enzyme modulation ▸ Enzyme inhibition ▸ Protease inhibition

Other / Curated residual function label ▸ Generic enzyme inhibition annotation

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length115 amino acids

Chemical FormulaC622H962N156O176S4

DescriptionStandard

        MRFQVYILHLCFFILVVLTYLSQGQSYTTTTTTSTTEQPTFLQKIHETFKKVKENAKIHNLYIFDPPTWIYTTTTEKPVESTENFDITNRQLITVPVRCPPNYDFIKGRCREKIP
    

Molecular Weight13569.49 Da

Isoelectric Point (pI)8.81

Net Charge (pH 7.0)2.74

Net Charge (pH 7.4) 2.30

Charge Density (pH 7.0) 0.0238

GRAVY Index-0.32

Hydrophobic Moment 0.73

Boman Index0.01

Instability Index39.01

Aliphatic Index 79.57

Aromaticity 0.1304

Extinction Coeff. Reduced 14440.00

Extinction Coeff. Oxidized 14565.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 5363.55

LogP -45.78

H-bond Donors 188.0

H-bond Acceptors 186.0

Rotatable Bonds 436.0

Heavy Atoms 958.0

Ring Count 27.0

Amide Bonds 125.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0053176 VERIFIED: YES

Provenance & Taxonomy

OrganismApis cerana [Animal]

FamilySecapin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibiotic Antifungal Anti-Gram-negative Anti-Gram-positive Protease inhibitor Serine protease inhibitor Cytotoxic Enzyme Inhibitor Non-hemolytic

TargetPseudomonas aeruginosa (Gram-negative)

RECORD: Rec_0250706 VERIFIED: YES

Provenance & Taxonomy

OrganismApis cerana [Animal]

FamilySecapin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibiotic Antifungal Anti-Gram-negative Anti-Gram-positive Protease inhibitor Serine protease inhibitor Cytotoxic Enzyme Inhibitor Non-hemolytic

TargetB. thuringiensis (Gram-positive)

RECORD: Rec_0265073 VERIFIED: YES

Provenance & Taxonomy

OrganismApis cerana [Animal]

FamilySecapin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibiotic Antifungal Anti-Gram-negative Anti-Gram-positive Protease inhibitor Serine protease inhibitor Cytotoxic Enzyme Inhibitor Non-hemolytic

TargetEscherichia coli (Gram-negative)

RECORD: Rec_0265780 VERIFIED: YES

Provenance & Taxonomy

OrganismApis cerana [Animal]

FamilySecapin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibiotic Antifungal Anti-Gram-negative Anti-Gram-positive Protease inhibitor Serine protease inhibitor Cytotoxic Enzyme Inhibitor Non-hemolytic

TargetP. larvae (Gram-positive)

RECORD: Rec_0266893 VERIFIED: YES

Provenance & Taxonomy

OrganismApis cerana [Animal]

FamilySecapin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibiotic Antifungal Anti-Gram-negative Anti-Gram-positive Protease inhibitor Serine protease inhibitor Cytotoxic Enzyme Inhibitor Non-hemolytic

TargetB. bassiana