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MYP_161219
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Basic Information
CCR5 ECL2 (178-191)
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition ▸ Fusion inhibitor
Standard
14 amino acids
C86H110N20O22S
Standard
Sequence
CSSHFPYSQYQFWK
Physicochemical Analysis
1807.98 Da
8.18
0.83
0.56
0.0596
-0.96
0.32
-0.00
32.38
0.00
0.3571
8480.00
8480.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
690.65
-5.15
25.0
25.0
52.0
129.0
8.0
15.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0183101 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-HIV-1 Entry inhibition
HIV-1 BaL26 | TZM-bl cells
65±3 μM
IC50
Mammalian: 1.2 h; Yeast: >20 h; E. coli: >10 h
PaperPeptides from second extracellular loop of C-C chemokine receptor type 5 (CCR5) inhibit diverse strains of HIV-1. | Dogo-Isonagie C, Lam S, Gustchina E, Acharya P, Yang Y, Shahzad-ul-Hussan S, Clore GM, Kwong PD, Bewley CA. | J Biol Chem. 2012 Apr 27;287(18):15076-86. | DOI:10.1074/jbc.M111.332361 | PMID:22403408 PMID22403408 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22403408/
RECORD: Rec_0190914 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
HIV-1 BaL26:inhibition of virus infection in TZM-bl cells
65±3 μM
IC50
PaperPubMed PMID: 22403408 PMID22403408 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22403408/
RECORD: Rec_0201382 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
HIV-1 HxB2:inhibition of virus infection in TZM-bl cells
54±2 μM
IC50
PaperPubMed PMID: 22403408 PMID22403408 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22403408/
RECORD: Rec_0254264 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
HIV-1 NL4-3:inhibition of virus infection in TZM-bl cells
53±2 μM
IC50
PaperPubMed PMID: 22403408 PMID22403408 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22403408/
RECORD: Rec_0292103 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Fusion inhibitor
TZM-bl
28 μM
IC50
PaperPeptides from second extracellular loop of C-C chemokine receptor type 5 (CCR5) inhibit diverse strains of HIV-1. PMID22403408 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22403408/
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