Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length191 amino acids

Chemical FormulaC935H1485N255O256S10

DescriptionStandard

        PTALPMAHEPMLLLAVTENVANSAAFTYFMSGALHRRISSDMLPHQFPLQLKTKRMGLLSPQLQERYPDHPMELELWARQQPLVSCHPRALHGTLFGSVEAFVVLPNATRVPAFLLNIDANVTAKPRITSTRLGGTVKLTGVGLSPACPSLGSGAACPVPQVKRVETLLKFGLWLFGVPWANSESLSPSCP
    

Molecular Weight20715.00 Da

Isoelectric Point (pI)9.32

Net Charge (pH 7.0)5.46

Net Charge (pH 7.4) 5.01

Charge Density (pH 7.0) 0.0286

GRAVY Index0.11

Hydrophobic Moment 0.55

Boman Index0.14

Instability Index60.13

Aliphatic Index 93.98

Aromaticity 0.0681

Extinction Coeff. Reduced 19480.00

Extinction Coeff. Oxidized 19730.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 7963.03

LogP -95.81

H-bond Donors 275.0

H-bond Acceptors 277.0

Rotatable Bonds 652.0

Heavy Atoms 1456.0

Ring Count 42.0

Amide Bonds 203.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0240992 VERIFIED: NO

Provenance & Taxonomy

OrganismRamphastos sulfuratus [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria