Peptide Database

Peptide NameDefensin alpha 4 (Antiadrenocorticotropin peptide IV) (Corticostatin IV) (CS-IV) (Corticostatin-4) (Macrophage antibiotic peptide MCP-2) (NP-2)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antifungal

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Standard StatusStandard

Sequence Length95 amino acids

Chemical FormulaC451H757N139O130S7

DescriptionStandard

        MRTLALLAAILLVALQAQAEHISVSIDEVVDQQPPQAEDQDVAIYVKEHESSALEALGVKAGVVCACRRALCLPLERRAGFCRIRGRIHPLCCRR
    

Molecular Weight10431.14 Da

Isoelectric Point (pI)7.63

Net Charge (pH 7.0)0.72

Net Charge (pH 7.4) 0.25

Charge Density (pH 7.0) 0.0076

GRAVY Index0.21

Hydrophobic Moment 0.46

Boman Index0.02

Instability Index58.50

Aliphatic Index 116.11

Aromaticity 0.0211

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1865.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 4310.86

LogP -40.26

H-bond Donors 156.0

H-bond Acceptors 141.0

Rotatable Bonds 349.0

Heavy Atoms 727.0

Ring Count 9.0

Amide Bonds 100.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0086533 VERIFIED: YES

Provenance & Taxonomy

OrganismOryctolagus cuniculus [Animal]

FamilyAlpha-defensin; Defensin

Tax ID9986

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfidedisulfide bond; sites not specified

Bio-Activity Profile

Function

Antimicrobial Defensin Antifungal Non-hemolytic

RECORD: Rec_0111920 VERIFIED: NO