Peptide Database

Peptide NameBactericidal permeability-increasing protein

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length503 amino acids

Chemical FormulaC2548H3957N633O744S17

DescriptionStandard

        MVQILWGCFLLWNLYISSAQTIYPGIKARATQRALDYGVQAGMDVIEQMVKERNIPDLKGSESLEFLKVEYVNYNFSNIKIHAFSFPNSSLAFVPGVGIKALTNHGSVNLSTNWDVKSPLFQDTGAADLFLSGVYFTGILILARNDFGHPTLELQDCYAQVSHAHVSFSGELSVLYNSFAEPMEKPILKNMNEMLCPIIMGEVEALNANLSMLEVLTKIDNYTILDYSLISSPEITENYVDLDLKGTFYPLENLTDPPFSPAPFVLPERSDSMLYVGISEYFFKSASFAYFTSGAFNVTLSTKEISSHLVRNSQGIGNVLSRLAEISILSQPFMVRIMATEPPVISLLPGNFTLDIPASIMILTETENSTVETIVSMDFVASTSVGLVILGQRLICSLSLNRFRLSLPESNRSNIEVLRFENILSSILHFGILPLANAKLQQGFPLPNPHKISFVNSDVEVLEHFILISTDLKYETSLKHPPSFHGWEGLNLISGQWKEKSAP
    

Molecular Weight55906.57 Da

Isoelectric Point (pI)5.05

Net Charge (pH 7.0)-17.51

Net Charge (pH 7.4) -18.45

Charge Density (pH 7.0) -0.0348

GRAVY Index0.15

Hydrophobic Moment 0.67

Boman Index0.18

Instability Index38.32

Aliphatic Index 103.48

Aromaticity 0.1014

Extinction Coeff. Reduced 51340.00

Extinction Coeff. Oxidized 51590.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0333137 VERIFIED: NO

Provenance & Taxonomy

OrganismRhinolophus ferrumequinum [Animal]

FamilyBPI/LBP

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic Non-ribosomal

TargetGram-negative bacteria

MethodQualitative functional evidence