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MYP_161072
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Basic Information
Rugosin-A (Frogs, amphibians, animals)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibiotic activity
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Defense peptide
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Standard
33 amino acids
C153H256N40O45S2
Standard
Sequence
GLLNTFKDWAISIAKGAGKGVLTTLSCKLDKSC
Physicochemical Analysis
3440.04 Da
9.24
2.74
2.50
0.0830
0.25
0.48
0.14
6.08
100.61
0.0606
5500.00
5625.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1379.48
-14.11
51.0
50.0
118.0
240.0
3.0
33.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0194852 VERIFIED: YES
Provenance & Taxonomy
Rana rugosa [Animal]
Rugosin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Pseudomonas aeruginosa PAO-1
100 μg/mL
MIC
PMID7612013 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/7612013/
RECORD: Rec_0205524 VERIFIED: YES
Provenance & Taxonomy
Glandirana rugosa [Animal]
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
27-33
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Micrococcus luteus ATCC9341
25 μg/mL
MIC
PMID7612013 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/7612013/
RECORD: Rec_0220784 VERIFIED: YES
Provenance & Taxonomy
Glandirana rugosa [Animal]
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
27-33
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Pseudomonas aeruginosa PAO-1
100 μg/mL
MIC
PMID7612013 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/7612013/
RECORD: Rec_0231296 VERIFIED: YES
Provenance & Taxonomy
Rana rugosa [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
27-33
Bio-Activity Profile
Antimicrobial
Micrococcus luteus ATCC 934
25 μg/mL
MIC
PaperIsolation and characterization of novel antimicrobial peptides, rugosins A, B and C, from the skin of the frog, Rana rugosa.
RECORD: Rec_0233157 VERIFIED: YES
Provenance & Taxonomy
Glandirana rugosa [Animal]
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
27-33
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Streptococcus pyogenes COOK
50 μg/mL
MIC
PMID7612013 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/7612013/
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