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MYP_161072
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Basic Information
Rugosin-A (Frogs, amphibians, animals)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibiotic activity
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Defense peptide
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Standard
33 amino acids
C153H256N40O45S2
Standard
Sequence
GLLNTFKDWAISIAKGAGKGVLTTLSCKLDKSC
Physicochemical Analysis
3440.04 Da
9.24
2.74
2.50
0.0830
0.25
0.48
0.14
6.08
100.61
0.0606
5500.00
5625.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1379.48
-14.11
51.0
50.0
118.0
240.0
3.0
33.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0101639 VERIFIED: YES
Provenance & Taxonomy
Japanese wrinkled [Animal]
33208
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PMID7999137 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/7999137/
RECORD: Rec_0142763 VERIFIED: NO
Provenance & Taxonomy
Glandirana rugosa [Animal]
Frog skin active peptide (FSAP)
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Amphibian defense peptide Antibiotic Antimicrobial Anti-Gram-positive Non-hemolytic Non-ribosomal
Gram-positive bacteria
Qualitative functional evidence
PMID7612013 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/7612013/; https://www.uniprot.org/uniprotkb/P80954/entry; https://bblserver.org.in/ampdb/
RECORD: Rec_0168734 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0172378 VERIFIED: YES
Provenance & Taxonomy
Glandirana rugosa [Animal]
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
27-33
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus 209P
6.25 μg/mL
MIC
PMID7612013 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/7612013/
RECORD: Rec_0182112 VERIFIED: YES
Provenance & Taxonomy
Rana rugosa [Animal]
Rugosin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Eschericia coli NIHJ
100 μg/mL
MIC
PMID7612013 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/7612013/
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