Peptide Database

Peptide NameCPE

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antiviral

Antiviral ▸ Anti-HIV ▸ Anti-HIV-1

Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length7 amino acids

Chemical FormulaC42H59N7O10S

DescriptionStandard

        CPFVFLE
    

Molecular Weight854.02 Da

Isoelectric Point (pI)4.60

Net Charge (pH 7.0)-1.24

Net Charge (pH 7.4) -1.46

Charge Density (pH 7.0) -0.1774

GRAVY Index1.57

Hydrophobic Moment 0.13

Boman Index0.60

Instability Index63.60

Aliphatic Index 97.14

Aromaticity 0.2857

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 266.43

LogP 0.80

H-bond Donors 9.0

H-bond Acceptors 10.0

Rotatable Bonds 23.0

Heavy Atoms 60.0

Ring Count 3.0

Amide Bonds 6.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0336428 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configcyclic/stapled peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermCyclization

C-TermCyclization

Bio-Activity Profile

Function

Antimicrobial Antiviral

RECORD: Rec_0384141 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyProtein-derived synthetic peptide

Tax ID32630

Structure & Mods

Configcyclic peptide architecture [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermCyclization (N termini to C termini)

C-TermCyclization (N termini to C termini)

Bio-Activity Profile

Function

Antiviral Anti-HIV-1 Fusion inhibition

Targetinhibition of cell-cell fusion between H9/HIV-1IIIB cells and MT-2 cells

Activity115.6±6.28 μM

MethodIC50

Half-LifeMammalian: 1.2 h; Yeast: >20 h; E. coli: >10 h

PaperShort cyclic peptides derived from the C-terminal sequence of α1-antitrypsin exhibit significant anti-HIV-1 activity. | Jia Q, Jiang X, Yu F, Qiu J, Kang X, Cai L, Li L, Shi W, Liu S, Jiang S, Liu K. | Bioorg Med Chem Lett. 2012 Apr 1;22(7):2393-5. | DOI:10.1016/j.bmcl.2012.02.037 | PMID:22406118 PMID22406118 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22406118/

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