Peptide Database

Peptide NameSLAY-screened peptide P2500

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length18 amino acids

Chemical FormulaC99H158N28O21S2

DescriptionStandard

        PLRRIASKLLHSFICPCW
    

Molecular Weight2140.62 Da

Isoelectric Point (pI)9.73

Net Charge (pH 7.0)3.02

Net Charge (pH 7.4) 2.89

Charge Density (pH 7.0) 0.1681

GRAVY Index0.46

Hydrophobic Moment 0.69

Boman Index0.11

Instability Index66.92

Aliphatic Index 113.89

Aromaticity 0.1111

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5625.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 769.99

LogP -3.75

H-bond Donors 31.0

H-bond Acceptors 27.0

Rotatable Bonds 66.0

Heavy Atoms 150.0

Ring Count 6.0

Amide Bonds 17.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0234583 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/