Peptide Database

Peptide NameGrowth hormone-releasing hormone

Function Ontology

Hormonal / Endocrine ▸ Hormone peptide

Metabolic

Neurological / Signaling ▸ Neuromodulation

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide

Standard StatusStandard

Sequence Length46 amino acids

Chemical FormulaC221H358N64O71S

DescriptionStandard

        HADDLLNKAYRNLLGQLSARKYLHTLMAKHLGAVSSSLEDDSEPLS
    

Molecular Weight5079.66 Da

Isoelectric Point (pI)6.28

Net Charge (pH 7.0)-0.97

Net Charge (pH 7.4) -1.34

Charge Density (pH 7.0) -0.0212

GRAVY Index-0.42

Hydrophobic Moment 0.71

Boman Index-0.05

Instability Index36.41

Aliphatic Index 101.96

Aromaticity 0.0435

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 2980.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 2187.07

LogP -23.36

H-bond Donors 76.0

H-bond Acceptors 74.0

Rotatable Bonds 172.0

Heavy Atoms 357.0

Ring Count 6.0

Amide Bonds 48.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0087248 VERIFIED: NO

Provenance & Taxonomy

OrganismRana ridibunda [Animal]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Hormone

RECORD: Rec_0094701 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Neuropeptide

Paper数据库级溯源文献：Wang Y, Wang M, Yin S, et al. NeuroPep: a comprehensive resource of neuropeptides. Database (Oxford). 2015:bav038. PMID 25931458; Bin Y, Zhang W, Tang W, et al. Prediction of Neuropeptides from Sequence Information Using Ensemble Classifier and Hybrid Features. J Proteome Res. 2020;19(9):3732-3740. PMID 32786686. PMID25931458;32786686 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25931458/

RECORD: Rec_0221931 VERIFIED: NO

Provenance & Taxonomy

OrganismPelophylax ridibundus [Animal]

FamilyGlucagon

Tax ID8406

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Hormone Metabolic

RECORD: Rec_0258047 VERIFIED: NO

Provenance & Taxonomy

OrganismPelophylax ridibundus [Animal]

FamilyGrowth hormone-releasing factor

Tax ID8406

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Hormone Endocrine Neuropeptide Neuromodulator

Half-LifeMammalian: 3.5 hour; Yeast: 10 min; E. coli: >10 hour