Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length507 amino acids

Chemical FormulaC2581H4005N643O741S17

DescriptionStandard

        MCTKIIPVLWGCFLLWNLYISSSQTIYPGIKARITQRALDYGVQAGMEMIEQMLRQKNLPNLSGSESLEFLKVDYVNYNFSNIKINAFSFPNTSLAFVPGVGIKALTNHGTANISTDWEFKSPIFQDTGGADLFLSGVYFTGIIILTRNDFGHPILKLQDCYAQVSHAHVSFSGELSVLYNSFAEPMEKPILKNLNEMLCPIIASEVEALNANLSTLEVLTKIDNYTLLDYSLISSPEITENHLDLNLKGVFYPLENLVDPYFSPVPFVLPERSNSMLYIGIAEYFFKSASFAYFTAGAFNVTLSTKEISNHFVQNSQGLGNVLSRIAEIYILSQPFMVRIMATEPPVINLQPGNFTLDIPASIMMLTQTKNSTVETIVSMDFVASTSVGLVILGQRLVCSLSLNRFRLALPESNRSNIEVLKFENILSSILHFGVLPLANAKLQQGFPLPNPHKISLVNSDIEVLEGFLLISTDLKYETSSKQHPSFHGWEGLNLISGWWRGKSAP
    

Molecular Weight56443.38 Da

Isoelectric Point (pI)5.53

Net Charge (pH 7.0)-9.62

Net Charge (pH 7.4) -10.53

Charge Density (pH 7.0) -0.0190

GRAVY Index0.16

Hydrophobic Moment 0.68

Boman Index0.19

Instability Index37.67

Aliphatic Index 103.83

Aromaticity 0.1065

Extinction Coeff. Reduced 58330.00

Extinction Coeff. Oxidized 58580.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0104344 VERIFIED: NO

Provenance & Taxonomy

OrganismAotus nancymaae [Animal]

FamilyBPI

Tax ID37293

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence