Peptide Database

Peptide NameInsulin-like growth factor I

Function Ontology

Hormonal / Endocrine ▸ Hormone peptide

Immunology ▸ Immune modulation ▸ Immunomodulatory activity

Metabolic

Neurological / Signaling ▸ Neuromodulation

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide

Regulatory peptide ▸ Biological modulation

Regulatory peptide ▸ Biological regulation

Reproductive biology ▸ Reproductive modulation

Standard StatusStandard

Sequence Length70 amino acids

Chemical FormulaC336H528N94O99S7

DescriptionStandard

        GPETLCGAELVDALQFVCGPRGFYFNKPTGYGSSIRRAPQTGIVDECCFRSCDLRRLEMYCAPLKPTKSA
    

Molecular Weight7692.81 Da

Isoelectric Point (pI)8.31

Net Charge (pH 7.0)1.71

Net Charge (pH 7.4) 1.40

Charge Density (pH 7.0) 0.0244

GRAVY Index-0.21

Hydrophobic Moment 0.60

Boman Index-0.02

Instability Index58.99

Aliphatic Index 64.14

Aromaticity 0.1000

Extinction Coeff. Reduced 4470.00

Extinction Coeff. Oxidized 4845.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 3080.84

LogP -32.36

H-bond Donors 113.0

H-bond Acceptors 108.0

Rotatable Bonds 245.0

Heavy Atoms 536.0

Ring Count 13.0

Amide Bonds 72.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0143180 VERIFIED: YES

Provenance & Taxonomy

OrganismRattus norvegicus [Animal]

FamilyInsulin

Tax ID10116

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Hormone Metabolic

RECORD: Rec_0191598 VERIFIED: YES

Provenance & Taxonomy

OrganismRattus norvegicus [Animal]

FamilyInsulin-like growth factor

Tax ID10116

Structure & Mods

Configdisulfide-constrained peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide6-48; 18-61; 47-52

Bio-Activity Profile

Function

Hormone Endocrine Neuropeptide Neuromodulator Metabolic regulation Physiological regulation Reproductive regulator Growth regulation Development regulation Receptor modulation Immunomodulatory

Half-LifeMammalian: 30 hour; Yeast: >20 hour; E. coli: >10 hour

RECORD: Rec_0249331 VERIFIED: YES

Provenance & Taxonomy

OrganismRattus norvegicus [Animal]

FamilyInsulin-like growth factor

Tax ID10116

Structure & Mods

Configdisulfide-constrained peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide6-48; 18-61; 47-52

Bio-Activity Profile

Function

Hormone Endocrine Neuropeptide Neuromodulator Metabolic regulation Physiological regulation Reproductive regulator Growth regulation Development regulation Receptor modulation Immunomodulatory

Targetintegrins and subsequent ternary complex formation with integrins and IGFR1 are essential for IGF1 signaling

Half-LifeMammalian: 30 hour; Yeast: >20 hour; E. coli: >10 hour

RECORD: Rec_0347306 VERIFIED: YES

Provenance & Taxonomy

OrganismRattus norvegicus [Animal]

FamilyInsulin-like growth factor

Tax ID10116

Structure & Mods

Configdisulfide-constrained peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide6-48; 18-61; 47-52

Bio-Activity Profile

Function

Hormone Endocrine Neuropeptide Neuromodulator Metabolic regulation Physiological regulation Reproductive regulator Growth regulation Development regulation Receptor modulation Immunomodulatory

Targetbone-derived osteoblastic (PyMS) cells

Half-LifeMammalian: 30 hour; Yeast: >20 hour; E. coli: >10 hour