Peptide Database

Peptide NameDEFA1 isoform 1 (DEFA1 isoform 2)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibiotic activity

Antimicrobial ▸ Antifungal

Antimicrobial ▸ Antifungal ▸ Fungicidal activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Standard StatusStandard

Sequence Length94 amino acids

Chemical FormulaC446H712N128O130S8

DescriptionStandard

        MRTLAILAAILLVALQAQAEPLQARGDEFAAAQEQIPADNPEVVVSLAWDKSLAPKDSGSRKNMACACRIPSCLAGERRYGTCFYQGRVWAFCC
    

Molecular Weight10203.72 Da

Isoelectric Point (pI)7.55

Net Charge (pH 7.0)0.45

Net Charge (pH 7.4) 0.13

Charge Density (pH 7.0) 0.0048

GRAVY Index0.09

Hydrophobic Moment 0.48

Boman Index0.06

Instability Index55.47

Aliphatic Index 87.45

Aromaticity 0.0745

Extinction Coeff. Reduced 13980.00

Extinction Coeff. Oxidized 14355.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 4131.10

LogP -40.93

H-bond Donors 148.0

H-bond Acceptors 139.0

Rotatable Bonds 331.0

Heavy Atoms 712.0

Ring Count 14.0

Amide Bonds 101.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0310073 VERIFIED: NO

Provenance & Taxonomy

OrganismPongo abelii [Bacterium]

FamilyDefensin

Tax ID9601

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Defensin Antifungal Fungicide Non-hemolytic

MethodQualitative functional evidence