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MYP_160727
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Basic Information
BmKDfsin4
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antiviral
Antiviral ▸ Anti-Hepatitis virus ▸ Anti-HBV
Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition
Membrane / Ion-channel modulation ▸ Ion channel modulation
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
37 amino acids
C181H278N62O48S6
Standard
Sequence
GFGCPFNQGQCHKHCQSIRRRGGYCDGFLKTRCVCYR
Physicochemical Analysis
4282.92 Da
9.38
5.87
5.47
0.1587
-0.71
0.58
-0.23
67.12
28.92
0.1351
2980.00
3355.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1811.61
-21.88
71.0
62.0
140.0
297.0
8.0
40.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0000146 VERIFIED: YES
Provenance & Taxonomy
Mesobuthus martensii [Animal]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antiviral
Micrococcus luteus AB93113
0.16 μM
MIC
PaperA Scorpion Defensin BmKDfsin4 Inhibits Hepatitis B Virus Replication in Vitro
RECORD: Rec_0008012 VERIFIED: YES
Provenance & Taxonomy
Buthus martensii,Mesobuthus martensii [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antiviral Channel blocker
1.26 μM
IC50
RECORD: Rec_0012041 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Anticancer
RECORD: Rec_0047019 VERIFIED: YES
Provenance & Taxonomy
Mesobuthus martensii [Animal]
Structure & Mods
cyclic/stapled peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
4-25, 11-33, 15-35
Bio-Activity Profile
Antimicrobial Antiviral Cytotoxic
L-02 cells
103
CC50
PaperPubMed PMID: 27128943 PMID27128943 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27128943/
RECORD: Rec_0050375 VERIFIED: YES
Provenance & Taxonomy
Mesobuthus martensii [Animal]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antiviral
Staphylococcus epidermidis PRSE P1389
0.31 μM
MIC
PaperA Scorpion Defensin BmKDfsin4 Inhibits Hepatitis B Virus Replication in Vitro
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