Peptide Database

Peptide NamePotassium channel toxin alpha-KTx 24.1

Function Ontology

Membrane / Ion-channel modulation ▸ Ion channel modulation

Venom / Toxin ▸ General toxin ▸ Toxin

Standard StatusStandard

Sequence Length33 amino acids

Chemical FormulaC127H209N45O45S8

DescriptionStandard

        VAKCSTSECGHACQQAGCRNSGCRYGSCICVGC
    

Molecular Weight3342.81 Da

Isoelectric Point (pI)8.21

Net Charge (pH 7.0)1.74

Net Charge (pH 7.4) 1.36

Charge Density (pH 7.0) 0.0528

GRAVY Index0.03

Hydrophobic Moment 0.49

Boman Index-0.02

Instability Index49.62

Aliphatic Index 38.48

Aromaticity 0.0303

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1990.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1460.97

LogP -24.88

H-bond Donors 60.0

H-bond Acceptors 56.0

Rotatable Bonds 109.0

Heavy Atoms 225.0

Ring Count 2.0

Amide Bonds 35.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0357011 VERIFIED: NO

Provenance & Taxonomy

OrganismPandinus imperator [Animal]

Structure & Mods

Configdisulfide-stabilized linear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide4-23; 9-28; 13-30; 18-33

Bio-Activity Profile

Function

Toxin Channel blocker

TargetKv1.2/KCNA2, Kv1.3/KCNA3