Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length497 amino acids

Chemical FormulaC2476H3908N626O706S20

DescriptionStandard

        MLPSLLVLLTLMPHAFAINPGIKASLSDKGLKYGSHVGASWLLEKTGQMVIPDVAGEIDIGIGTVHYWLTSMKISQINLPEPTVTFMEKVGIKVSMENLNVAVHGNWNTKFSFIKDGGTFDLAVINVGLSTVIQLGSDGKGHLSVANVQCSSSIGGIDASFHGGGSFIFQPFVHFFKSKILNQIQEKICPGIEKYVNDLESQLEKMQGTTANKTQKKSAFCVFVTSCVRPCNVYHCVPVSFQVNRNLSIELPLVLPPIIQSSDVEVDLKGVFYGARNHTDPPFAAGPFQLVQQSDLMLTVGLSEFTINSASFAYYSAGLLQILITDDMIPKASPFRLNTTSFGTLIPQLPKMYPNMLMLLRAYAAQTPTVSFHPDTTTLNVFVSTKAYGIKPNATYIPFFRLDMNATLSSKFFISDEKLSGSTALDNLTLTVGATEIGPFQTESLQKLLQIGIKSYLLPLLNKKLKDGIPLPTVHNVQWVNSMLKVNKVNKNPLQQI
    

Molecular Weight54382.58 Da

Isoelectric Point (pI)8.69

Net Charge (pH 7.0)5.42

Net Charge (pH 7.4) 4.45

Charge Density (pH 7.0) 0.0109

GRAVY Index0.14

Hydrophobic Moment 0.63

Boman Index0.18

Instability Index31.19

Aliphatic Index 99.40

Aromaticity 0.0885

Extinction Coeff. Reduced 39880.00

Extinction Coeff. Oxidized 40255.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0029758 VERIFIED: NO

Provenance & Taxonomy

OrganismParamormyrops kingsleyae [Bacterium]

FamilyBPI

Tax ID1676925

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence