Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length651 amino acids

Chemical FormulaC3192H5024N890O892S28

DescriptionStandard

        MKFLGGGIWMRAQRGVWGCLGNDAQSQKSHPITHAHHTYPTHITHTPPTPPPPSPYISHTQHHHTHCYTHTPYMPAKHAPPPHTHTQTCVHTHMSHAHLLPLTPQLPGSTLGPNHGRQQPSPSPAPTQFPSSFLHPTGLHFPSQLLYRSLAPLQGLKALAALEDEDMARHPDNALRWATLLVLAILGTAAVVTTTNPGVVARITQKGLDYACQQGVAVLQKELEKIKIPTFSGSFKVKHLGKGHYSFYSMVIRGFQLPSSQIKLVPNKGLDLSIRNANIKISGKWKARKNFIKTSGNFDLSVESISISAGLNMSFDPTSGHLTIICSSCNNYIDSVRVHISGGRLGWLIQLFHKKIESAIRKTMNNKICQVVSSSVSSRLQSYLKTLPVTYKIDRIAGISYSLVAPPTATADNLDGHLKGEFFSLAHPRSPPFTPPAMALPPDHDHMVYLGISDYFFNTAGLVYQEAGALNMTITDDMIPKKSKFRLTTDFLGTLIPQVAEMFPNMTVQFNVWASSPPHLTMRPAGLIFTPTLDTQAFAVLPNSSLAPLFVLGLSTNLSMEVSARPDRLVGQLSLDKLLLELKHSDVGSFSVAVLQSIMNYVVPTAVLPKVNGLPAVWCRCSLQRLKSRIQRGCRGAVGPARRCGAGGSGS
    

Molecular Weight71037.28 Da

Isoelectric Point (pI)9.69

Net Charge (pH 7.0)28.36

Net Charge (pH 7.4) 26.16

Charge Density (pH 7.0) 0.0436

GRAVY Index-0.11

Hydrophobic Moment 0.81

Boman Index0.09

Instability Index41.13

Aliphatic Index 86.45

Aromaticity 0.0737

Extinction Coeff. Reduced 62340.00

Extinction Coeff. Oxidized 62965.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0135977 VERIFIED: NO

Provenance & Taxonomy

OrganismCanis lupus familiaris (Dog) [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria