Peptide Database

Peptide NameMaximin H5

Function Ontology

Anticancer

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antifungal

Antiviral

Antiviral ▸ Anti-HIV ▸ Anti-HIV-1

Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition

Reproductive biology ▸ Contraceptive activity ▸ Spermicidal

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC93H160N20O29

DescriptionStandard

        ILGPVLGLVSDTLDDVLGIL
    

Molecular Weight2022.38 Da

Isoelectric Point (pI)4.05

Net Charge (pH 7.0)-3.24

Net Charge (pH 7.4) -3.44

Charge Density (pH 7.0) -0.1618

GRAVY Index1.48

Hydrophobic Moment 0.44

Boman Index0.55

Instability Index26.63

Aliphatic Index 199.50

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 759.79

LogP -3.86

H-bond Donors 25.0

H-bond Acceptors 26.0

Rotatable Bonds 65.0

Heavy Atoms 142.0

Ring Count 1.0

Amide Bonds 19.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0278976 VERIFIED: YES

Provenance & Taxonomy

OrganismBombina maxima [Animal]

FamilyMaximin

Tax ID161274

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antiviral Anti-HIV-1 Entry inhibition

TargetHIV-1 IIIB | CEM-SS cells

Activity49.4 μM

MethodEC50

Half-LifeMammalian: 20 h; Yeast: 30 min; E. coli: >10 h

PaperIdentification of novel human immunodeficiency virus type 1-inhibitory peptides based on the antimicrobial peptide database. | Wang G, Watson KM, Peterkofsky A, Buckheit RW Jr. | Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6. | DOI:10.1128/AAC.01448-09 | PMID:20086159 PMID20086159 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20086159/

RECORD: Rec_0345999 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial

RECORD: Rec_0415857 VERIFIED: YES

Provenance & Taxonomy

OrganismBombina maxima [Animal]

Tax ID161274

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antiviral Anticancer

TargetStaphylococcus aureus

Activity90 μM

MethodMIC

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