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MYP_160527
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Basic Information
Bacteriocin Astexin-1
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Standard
23 amino acids
C110H168N30O42
Standard
Sequence
GLSQGVEPDIGQTYFEESRINQD
Physicochemical Analysis
2582.69 Da
4.05
-4.23
-4.44
-0.1838
-0.98
0.45
-0.10
59.05
63.48
0.0870
1490.00
1490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1196.41
-14.71
39.0
38.0
86.0
182.0
3.0
26.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0073493 VERIFIED: NO
Provenance & Taxonomy
Asticcacaulis excentricus CB 48 [Bacterium]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
RECORD: Rec_0247196 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
PaperCAMP: Collection of sequences and structures of antimicrobial peptides PMID24265220 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24265220/
RECORD: Rec_0251900 VERIFIED: YES
Provenance & Taxonomy
Asticcacaulis excentricus [Bacterium]; Bacteria [Bacterium]
2; 2
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PMID22838838 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22838838/
RECORD: Rec_0290646 VERIFIED: YES
Provenance & Taxonomy
Asticcacaulis excentricus [Bacterium]
Bacteriocin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Identified through a bioinformatic mining of genomes. It is the largest lasso discovered till 2012. Chemical modification: An amide bond formed between N-terminal G1 and D9, excluding the possible G1-E7 connection
Bio-Activity Profile
Antimicrobial
PaperPrecursor-centric genome-mining approach for lasso peptide discovery.
RECORD: Rec_0353646 VERIFIED: YES
Provenance & Taxonomy
Asticcacaulis excentricus [Bacterium]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
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