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MYP_160489
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Basic Information
Apelin-12
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition ▸ Entry inhibitor
Standard
12 amino acids
C64H103N21O14S
Standard
Sequence
RPRLSHKGPMPF
Physicochemical Analysis
1422.70 Da
12.00
2.85
2.59
0.2372
-1.13
0.45
-0.28
77.97
32.50
0.0833
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
555.78
-4.46
19.0
19.0
42.0
100.0
5.0
11.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0357408 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
HIV:Inhibition of HIV infection in NP-2/CD4/APJ cells
63 μg/mL
IC50
PaperPubMed PMID: 10802050 PMID10802050 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10802050/
RECORD: Rec_0406153 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-HIV Entry inhibition
HIV | NP-2/CD4/APJ cells
44.28 μM
IC50
Mammalian: 1 h; Yeast: 2 min; E. coli: 2 min
PaperApelin peptides block the entry of human immunodeficiency virus (HIV). | Zou MX, Liu HY, Haraguchi Y, Soda Y, Tatemoto K, Hoshino H. | FEBS Lett. 2000 May 4;473(1):15-8. | DOI:10.1016/s0014-5793(00)01487-3 | PMID:10802050 PMID10802050 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10802050/
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