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MYP_160349
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Basic Information
Temporin-1RNa
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
12 amino acids
C68H127N17O14
Standard
Sequence
ILPIRSLIKKLL
Physicochemical Analysis
1406.84 Da
11.17
2.76
2.55
0.2298
1.17
0.57
0.23
63.73
227.50
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
508.80
0.07
18.0
17.0
49.0
99.0
1.0
11.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0012515 VERIFIED: YES
Provenance & Taxonomy
Rana nigromaculata [Animal]
Temporin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Candida albicans
12.5 μM
MIC
PMID23632907 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23632907/
RECORD: Rec_0042287 VERIFIED: YES
Provenance & Taxonomy
Amphibia [Animal]
Temporin
8292
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PMID23935531 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23935531/
RECORD: Rec_0088756 VERIFIED: YES
Provenance & Taxonomy
Rana nigromaculata [Animal]
Temporin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anticancer Cytotoxic
Human breast adenocarcinoma MCF-7
23.4
IC50
PMID23632907 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23632907/
RECORD: Rec_0104578 VERIFIED: YES
Provenance & Taxonomy
Rana nigromaculata [Animal]
Temporin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Anticancer
cancer cells MCF 7 cells and Hela cells
~25 μM
IC50
PaperPurification, molecular cloning, and antimicrobial activity of peptides from the skin secretion of the black-spotted frog, Rana nigromaculata.
RECORD: Rec_0123414 VERIFIED: YES
Provenance & Taxonomy
Animalia [Animal]
Temporin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Anticancer Cytotoxic
PMID23632907 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23632907/
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