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MYP_160184
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Basic Information
VG-PEG24-Chol
Antiviral
Antiviral ▸ Anti-Influenza virus
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition
not Standard
42 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
VALDPIDISIVLNKAKSDLEESKEWIRRSNGKLDSIGSGSGX
Physicochemical Analysis
0.00 Da
0.00
0.00
0.00
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0301336 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Fusion-inhibitory peptide
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Acetylation
Amidation
The 'X' at position 42 indicates cholesterol-PEG24 conjugated cysteine.
Bio-Activity Profile
Antiviral Anti-Influenza virus Fusion inhibition
Human parainfluenza virus 3 (HPIV-3) | Vero cells
0.0001±0.0000003 μM
IC90
Mammalian: 100 h; Yeast: >20 h; E. coli: >10 h
PaperBroad spectrum antiviral activity for paramyxoviruses is modulated by biophysical properties of fusion inhibitory peptides | Mathieu C, Augusto MT, Niewiesk S, Horvat B, Palermo LM, Sanna G, Madeddu S, Huey D, Castanho MA, Porotto M, Santos NC, Moscona A | Sci Rep. 2017 Mar 8;7:43610. | DOI:10.1038/srep43610 | PMID:28344321 PMID28344321 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28344321/
RECORD: Rec_0326684 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Fusion-inhibitory peptide
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Acetylation
Amidation
The 'X' at position 42 indicates cholesterol-PEG4 conjugated cysteine.
Bio-Activity Profile
Antiviral Anti-Influenza virus Fusion inhibition
Human parainfluenza virus 3 (HPIV-3) | Vero cells
0.0007±0.000007 μM
IC90
Mammalian: 100 h; Yeast: >20 h; E. coli: >10 h
PaperBroad spectrum antiviral activity for paramyxoviruses is modulated by biophysical properties of fusion inhibitory peptides | Mathieu C, Augusto MT, Niewiesk S, Horvat B, Palermo LM, Sanna G, Madeddu S, Huey D, Castanho MA, Porotto M, Santos NC, Moscona A | Sci Rep. 2017 Mar 8;7:43610. | DOI:10.1038/srep43610 | PMID:28344321 PMID28344321 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28344321/
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