‹ ›
MYP_160184
← PREVIOUS NEXT → BACK
Basic Information
VG-PEG24-Chol
Antiviral
Antiviral ▸ Anti-Influenza virus
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition
not Standard
42 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
VALDPIDISIVLNKAKSDLEESKEWIRRSNGKLDSIGSGSGX
Physicochemical Analysis
0.00 Da
0.00
0.00
0.00
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.
2D CHEMICAL STRUCTURE
Drag to move
Drag to move. Use the buttons to zoom.
Experimental Records
RECORD: Rec_0015446 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Fusion-inhibitory peptide
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Acetylation
Amidation
The 'X' at position 42 indicates cholesterol-PEG24 conjugated cysteine.
Bio-Activity Profile
Antiviral Fusion inhibition
Nipah virus (NiV) | Vero cells
0.002 μM
IC90
Mammalian: 100 h; Yeast: >20 h; E. coli: >10 h
PaperBroad spectrum antiviral activity for paramyxoviruses is modulated by biophysical properties of fusion inhibitory peptides | Mathieu C, Augusto MT, Niewiesk S, Horvat B, Palermo LM, Sanna G, Madeddu S, Huey D, Castanho MA, Porotto M, Santos NC, Moscona A | Sci Rep. 2017 Mar 8;7:43610. | DOI:10.1038/srep43610 | PMID:28344321 PMID28344321 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28344321/
RECORD: Rec_0043826 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Fusion-inhibitory peptide
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Acetylation
Amidation
The 'X' at position 42 indicates cholesterol-conjugated cysteine.
Bio-Activity Profile
Antiviral Anti-Influenza virus Fusion inhibition
Human parainfluenza virus 3 (HPIV-3) | Vero cells
0.0007±0.00026 μM
IC90
Mammalian: 100 h; Yeast: >20 h; E. coli: >10 h
PaperBroad spectrum antiviral activity for paramyxoviruses is modulated by biophysical properties of fusion inhibitory peptides | Mathieu C, Augusto MT, Niewiesk S, Horvat B, Palermo LM, Sanna G, Madeddu S, Huey D, Castanho MA, Porotto M, Santos NC, Moscona A | Sci Rep. 2017 Mar 8;7:43610. | DOI:10.1038/srep43610 | PMID:28344321 PMID28344321 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28344321/
RECORD: Rec_0089512 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Fusion-inhibitory peptide
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Acetylation
Amidation
The 'X' at position 42 indicates cholesterol-PEG24 conjugated cysteine.
Bio-Activity Profile
Antiviral Anti-Influenza virus Fusion inhibition
Human parainfluenza virus 3 (HPIV-3) | Vero cells
0.000007±0.000007 μM
IC50
Mammalian: 100 h; Yeast: >20 h; E. coli: >10 h
PaperBroad spectrum antiviral activity for paramyxoviruses is modulated by biophysical properties of fusion inhibitory peptides | Mathieu C, Augusto MT, Niewiesk S, Horvat B, Palermo LM, Sanna G, Madeddu S, Huey D, Castanho MA, Porotto M, Santos NC, Moscona A | Sci Rep. 2017 Mar 8;7:43610. | DOI:10.1038/srep43610 | PMID:28344321 PMID28344321 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28344321/
RECORD: Rec_0156268 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Fusion-inhibitory peptide
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Acetylation
Amidation
The 'X' at position 42 indicates cholesterol-conjugated cysteine.
Bio-Activity Profile
Antiviral Anti-Influenza virus Fusion inhibition
Human parainfluenza virus 3 (HPIV-3) | Vero cells
0.000015±0.00007 μM
IC50
Mammalian: 100 h; Yeast: >20 h; E. coli: >10 h
PaperBroad spectrum antiviral activity for paramyxoviruses is modulated by biophysical properties of fusion inhibitory peptides | Mathieu C, Augusto MT, Niewiesk S, Horvat B, Palermo LM, Sanna G, Madeddu S, Huey D, Castanho MA, Porotto M, Santos NC, Moscona A | Sci Rep. 2017 Mar 8;7:43610. | DOI:10.1038/srep43610 | PMID:28344321 PMID28344321 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28344321/
RECORD: Rec_0300327 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Fusion-inhibitory peptide
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Acetylation
Amidation
The 'X' at position 42 indicates cholesterol-PEG4 conjugated cysteine.
Bio-Activity Profile
Antiviral Anti-Influenza virus Fusion inhibition
Human parainfluenza virus 3 (HPIV-3) | Vero cells
0.00003±0.00004 μM
IC50
Mammalian: 100 h; Yeast: >20 h; E. coli: >10 h
PaperBroad spectrum antiviral activity for paramyxoviruses is modulated by biophysical properties of fusion inhibitory peptides | Mathieu C, Augusto MT, Niewiesk S, Horvat B, Palermo LM, Sanna G, Madeddu S, Huey D, Castanho MA, Porotto M, Santos NC, Moscona A | Sci Rep. 2017 Mar 8;7:43610. | DOI:10.1038/srep43610 | PMID:28344321 PMID28344321 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28344321/
1 2 NEXT LAST
Showing 5 records on this page · Page 1 of 2