Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length124 amino acids

Chemical FormulaC629H996N178O168S3

DescriptionStandard

        RMMARPYHVVVVLLLLESSVRFGEGASNPGVVARITTKGLEYANQYAVATLRKELPAIRLPDFSGNFKIGWFGRVSYNFHSLKIHRFEVRNSDLSLLPGLGIRASLSNNDLSLGGNWKVKKGFM
    

Molecular Weight13835.92 Da

Isoelectric Point (pI)10.38

Net Charge (pH 7.0)9.03

Net Charge (pH 7.4) 8.65

Charge Density (pH 7.0) 0.0728

GRAVY Index-0.02

Hydrophobic Moment 0.60

Boman Index0.06

Instability Index17.08

Aliphatic Index 98.23

Aromaticity 0.1048

Extinction Coeff. Reduced 16960.00

Extinction Coeff. Oxidized 16960.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 5567.78

LogP -49.81

H-bond Donors 197.0

H-bond Acceptors 183.0

Rotatable Bonds 458.0

Heavy Atoms 978.0

Ring Count 23.0

Amide Bonds 132.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0334760 VERIFIED: NO

Provenance & Taxonomy

OrganismMarmota marmota marmota [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria

MethodQualitative functional evidence