Peptide Database

Peptide NameRJ9-I15

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antiviral

Antiviral ▸ Anti-Herpesvirus ▸ Anti-HSV

Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition

Enzyme modulation ▸ Enzyme inhibition ▸ Infection inhibition

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length21 amino acids

Chemical FormulaC108H211N35O22

DescriptionStandard

        AKKAKKKAKKAAKKIKKKAKK
    

Molecular Weight2352.05 Da

Isoelectric Point (pI)11.11

Net Charge (pH 7.0)13.78

Net Charge (pH 7.4) 13.57

Charge Density (pH 7.0) 0.6563

GRAVY Index-1.87

Hydrophobic Moment 0.72

Boman Index-0.76

Instability Index1.44

Aliphatic Index 47.14

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1009.60

LogP -7.93

H-bond Donors 36.0

H-bond Acceptors 36.0

Rotatable Bonds 99.0

Heavy Atoms 165.0

Ring Count 0.0

Amide Bonds 20.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0357697 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilySynthetic peptide

Tax ID32630

Structure & Mods

Configsynthetic linear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antiviral Anti-HSV Entry inhibition

TargetHerpes simplex virus 1(HSV-1) | Vero cells

Activity11 μM

MethodIC50

Half-LifeMammalian: 4.4 h; Yeast: >20 h; E. coli: >10 h

PaperPrediction of activity, synthesis and biological testing of anti-HSV active peptides. | Jenssen H, Gutteberg TJ, Rekdal Ø, Lejon T. | Chem Biol Drug Des. 2006 Jul;68(1):58-66. | DOI:10.1111/j.1747-0285.2006.00412.x | PMID:16923027 PMID16923027 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16923027/

RECORD: Rec_0418340 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antimicrobial Antiviral Cytotoxic

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