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MYP_160110
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Basic Information
[D-Lys18] Ascaphin-8
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
19 amino acids
C97H164N24O23
Standard
Sequence
GFKDLLKGAAKALVKTVKF
Physicochemical Analysis
2034.49 Da
10.18
3.76
3.55
0.1977
0.33
0.68
0.11
-14.87
107.89
0.1053
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
774.75
-4.12
27.0
27.0
72.0
144.0
2.0
18.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0133838 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Ascaphin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Escherichia coli ATCC 25726
6 μM
MIC
PMID18554256 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18554256/
RECORD: Rec_0155054 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Anticancer Hemolytic
Human erythrocytes
500 μM
LC50
PMID18554256 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18554256/
RECORD: Rec_0155405 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 42.1%, E 0.0%, T 36.8%, C 21.1% [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Toxic Antimicrobial Hemolytic
PaperHemolytik: a database of experimentally determined hemolytic and non-hemolytic peptides PMID24174543 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24174543/
RECORD: Rec_0188697 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
mixed L/D or modified amino-acid peptide [Mixed]
None
Amidation
Bio-Activity Profile
Antimicrobial Anticancer Cytotoxic
fibroblast-derived cells
65 μM
LC50
PMID18554256 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18554256/
RECORD: Rec_0224450 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Ascaphin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Staphylococcus aureus ATCC 25923
50 μM
MIC
PMID18554256 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18554256/
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