Peptide Database

Peptide NameNK-2 (Mammals, Animals)

Function Ontology

Anticancer

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antibacterial ▸ Anti-Mycobacterium

Antimicrobial ▸ Antifungal

Antiparasitic ▸ Antimalarial

Antiparasitic ▸ Antiprotozoal ▸ Antimalarial ▸ Anti-Plasmodium

Antiparasitic ▸ General antiparasitic ▸ Antiparasitic

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Toxic

Standard StatusStandard

Sequence Length27 amino acids

Chemical FormulaC143H261N45O33S2

DescriptionStandard

        KILRGVCKKIMRTFLRRISKDILTGKK
    

Molecular Weight3203.01 Da

Isoelectric Point (pI)11.60

Net Charge (pH 7.0)8.75

Net Charge (pH 7.4) 8.52

Charge Density (pH 7.0) 0.3239

GRAVY Index-0.26

Hydrophobic Moment 0.87

Boman Index-0.28

Instability Index45.43

Aliphatic Index 111.85

Aromaticity 0.0370

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1321.63

LogP -9.77

H-bond Donors 51.0

H-bond Acceptors 44.0

Rotatable Bonds 119.0

Heavy Atoms 223.0

Ring Count 1.0

Amide Bonds 26.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0325381 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

FamilyNK-2-derived peptide

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermAmidation

Bio-Activity Profile

Function

Anticancer Cytotoxic

TargetU-937

Activity30 μM

MethodLD50

RECORD: Rec_0376978 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

FamilyNK-2-derived peptide

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermAmidation

Bio-Activity Profile

Function

Antibacterial

TargetSH-SY5Y

Activity1-4 μM

MethodLD50

RECORD: Rec_0384742 VERIFIED: YES

Provenance & Taxonomy

OrganismSus scrofa [Animal]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermAmidation

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Anticancer Cytotoxic

TargetHL-60

RECORD: Rec_0390910 VERIFIED: YES

Provenance & Taxonomy

OrganismSus scrofa [Animal]

FamilyNK-2-derived peptide

Tax ID9823

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermAmidation

Bio-Activity Profile

Function

Anticancer

TargetE42/02

Activity40 μM

MethodIC50

RECORD: Rec_0391761 VERIFIED: YES

Provenance & Taxonomy

OrganismSus scrofa [Animal]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermAmidation

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Anticancer Cytotoxic

TargetPC-3

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