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MYP_160083
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Basic Information
NK-2 (Mammals, Animals)
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibacterial ▸ Anti-Mycobacterium
Antimicrobial ▸ Antifungal
Antiparasitic ▸ Antimalarial
Antiparasitic ▸ Antiprotozoal ▸ Antimalarial ▸ Anti-Plasmodium
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
27 amino acids
C143H261N45O33S2
Standard
Sequence
KILRGVCKKIMRTFLRRISKDILTGKK
Physicochemical Analysis
3203.01 Da
11.60
8.75
8.52
0.3239
-0.26
0.87
-0.28
45.43
111.85
0.0370
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1321.63
-9.77
51.0
44.0
119.0
223.0
1.0
26.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0173945 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
NK-2-derived peptide
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Anticancer Cytotoxic
SW-480
1-4 μM
LD50
PMID16269280 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16269280/
RECORD: Rec_0208754 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
NK-lysin
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
None
Amidation
Bio-Activity Profile
Antimicrobial Antimycobacterial
Mycobacterium smegmatis mc2155
30 μM
MIC
PMID21396418 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21396418/
RECORD: Rec_0212841 VERIFIED: YES
Provenance & Taxonomy
Mammal [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Anticancer
Pseudomonas aeruginosa
8 μM
MIC
PMID29043494 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29043494/
RECORD: Rec_0222152 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Cytotoxic
Human erythrocytes
100 μg/mL
Hemolysis
Paperhttps://pubmed.ncbi.nlm.nih.gov/17389605/ PMID17389605 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17389605/
RECORD: Rec_0225070 VERIFIED: YES
Provenance & Taxonomy
Mammal [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Anticancer
Staphylococcus epidermidis
2 μM
MIC
PMID29043494 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29043494/
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