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MYP_160083
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Basic Information
NK-2 (Mammals, Animals)
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibacterial ▸ Anti-Mycobacterium
Antimicrobial ▸ Antifungal
Antiparasitic ▸ Antimalarial
Antiparasitic ▸ Antiprotozoal ▸ Antimalarial ▸ Anti-Plasmodium
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
27 amino acids
C143H261N45O33S2
Standard
Sequence
KILRGVCKKIMRTFLRRISKDILTGKK
Physicochemical Analysis
3203.01 Da
11.60
8.75
8.52
0.3239
-0.26
0.87
-0.28
45.43
111.85
0.0370
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1321.63
-9.77
51.0
44.0
119.0
223.0
1.0
26.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0093415 VERIFIED: YES
Provenance & Taxonomy
Sus scrofa [Animal]
NK-lysin-derived
9823
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Amidation
Bio-Activity Profile
Anticancer Antimicrobial
PC-3
PaperThe NK-lysin derived peptide NK-2 preferentially kills cancer cells with increased surface levels of negatively charged phosphatidylserine PMID16269280 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16269280/
RECORD: Rec_0099092 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
NK-2-derived peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial
E42/02
~40 μM
IC50
PMID23893605 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23893605/
RECORD: Rec_0127534 VERIFIED: YES
Provenance & Taxonomy
Sus scrofa [Animal]
NK-2-derived peptide
9823
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Anticancer
E42/02
4.3±0.3 μM
IC50
PMID23893605 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23893605/
RECORD: Rec_0137871 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630.0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Pseudomonas aeruginosa
8 μM
MIC
PMID29043494 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29043494/
RECORD: Rec_0149841 VERIFIED: YES
Provenance & Taxonomy
Mammal [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Anticancer
Staphylococcus aureus
2 μM
MIC
PMID29043494 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29043494/
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