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MYP_160083
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Basic Information
NK-2 (Mammals, Animals)
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibacterial ▸ Anti-Mycobacterium
Antimicrobial ▸ Antifungal
Antiparasitic ▸ Antimalarial
Antiparasitic ▸ Antiprotozoal ▸ Antimalarial ▸ Anti-Plasmodium
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
27 amino acids
C143H261N45O33S2
Standard
Sequence
KILRGVCKKIMRTFLRRISKDILTGKK
Physicochemical Analysis
3203.01 Da
11.60
8.75
8.52
0.3239
-0.26
0.87
-0.28
45.43
111.85
0.0370
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1321.63
-9.77
51.0
44.0
119.0
223.0
1.0
26.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0041816 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 70.4%, E 0.0%, T 14.8%, C 14.8% [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Anticancer Antibacterial Antiparasitic Toxic Antimicrobial Antiplasmodial Hemolytic Cytotoxic
PaperCancerPPD: a database of anticancer peptides and proteins PMID25270878 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25270878/
RECORD: Rec_0076844 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anticancer
PaperAntiCP 2.0: an updated model for predicting anticancer peptides (benchmark provenance; exact sequence-level experiment paper unresolved here) | https://pubmed.ncbi.nlm.nih.gov/32770192/
RECORD: Rec_0082663 VERIFIED: YES
Provenance & Taxonomy
Sus scrofa [Animal]
NK-2-derived peptide
9823
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Anticancer
E42/02
70 μM
IC50
PMID23893605 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23893605/
RECORD: Rec_0085426 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630.0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli
4 μM
MIC
PMID29043494 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29043494/
RECORD: Rec_0089966 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
NK-lysin
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
None
Amidation
Bio-Activity Profile
Antimicrobial Antimycobacterial Antibacterial Antifungal
Mycobacterium marinum (ATCC 927)
MIC
PMID23689720 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23689720/
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