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MYP_159927
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Basic Information
peptide 15
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
not Standard
9 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
XXWXXXWWX
Physicochemical Analysis
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0.00
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0181861 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
X=Dab ((S)-2,4-diaminobutyric acid)
Bio-Activity Profile
Antimicrobial Anticancer
Tumor cells: AT84
14.3±1.2 μM
IC50
PaperDiscovery of a 9-mer Cationic Peptide (LTX-315) as a Potential First in Class Oncolytic Peptide. J Med Chem. 2016 Apr 14;59(7):2918-27. doi: 10.1021/acs.jmedchem.5b02025. PMID: 26982623. PMID26982623 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26982623/
RECORD: Rec_0182963 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
X(1/2/5/6/9)=ornithine; X(4)=Dip (Diphenylalanine)
Bio-Activity Profile
Antimicrobial Anticancer Hemolytic
Human red blood cells (RBC)
695 μM
IC50
PaperPubMed PMID: 21453492 PMID21453492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21453492/
RECORD: Rec_0185200 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
X=Dab ((S)-2,4-diaminobutyric acid)
Bio-Activity Profile
Antimicrobial Anticancer
Kelly
78±7 μM
IC50
PaperDiscovery of a 9-mer Cationic Peptide (LTX-315) as a Potential First in Class Oncolytic Peptide. J Med Chem. 2016 Apr 14;59(7):2918-27. doi: 10.1021/acs.jmedchem.5b02025. PMID: 26982623. PMID26982623 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26982623/
RECORD: Rec_0189989 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
X=Dap ((S)-2,3-diaminopropionic acid)
Bio-Activity Profile
Antimicrobial Anticancer
AT84
23±3.6 μM
IC50
PaperDiscovery of a 9-mer Cationic Peptide (LTX-315) as a Potential First in Class Oncolytic Peptide. J Med Chem. 2016 Apr 14;59(7):2918-27. doi: 10.1021/acs.jmedchem.5b02025. PMID: 26982623. PMID26982623 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26982623/
RECORD: Rec_0205443 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
X(1/2/5/6/9)=ornithine; X(4)=Dip (Diphenylalanine)
Bio-Activity Profile
Antimicrobial Anticancer
A20
8.3±0.6 μM
IC50
PaperPubMed PMID: 21453492 PMID21453492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21453492/
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