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MYP_159920
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Basic Information
BmKDfsin3
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antiviral
Antiviral ▸ Anti-Hepatitis virus ▸ Anti-HCV
Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
38 amino acids
C190H299N69O47S6
Standard
Sequence
GFGCPFNQGKCHRHCRSIRRRGGYCDGFLKQRCVCYRK
Physicochemical Analysis
4494.23 Da
10.00
8.87
8.47
0.2334
-0.92
0.79
-0.37
72.41
28.16
0.1316
2980.00
3355.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1927.21
-22.38
77.0
64.0
150.0
312.0
8.0
40.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0036815 VERIFIED: YES
Provenance & Taxonomy
Mesobuthus martensii [Animal]
Structure & Mods
side-chain cyclized peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
4-25, 11-33, 15-35
Bio-Activity Profile
Antimicrobial Antiviral
PMID31963532 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31963532/
RECORD: Rec_0105208 VERIFIED: YES
Provenance & Taxonomy
Mesobuthus martensii [Animal]
Structure & Mods
side-chain cyclized peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
4-25, 11-33, 15-35
Bio-Activity Profile
Antimicrobial Antiviral Cytotoxic
cells:CC50=60
PMID31963532 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31963532/
RECORD: Rec_0261106 VERIFIED: YES
Provenance & Taxonomy
Mesobuthus martensii [Animal]
Structure & Mods
side-chain cyclized peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
4-25, 11-33, 15-35
Bio-Activity Profile
Antimicrobial Antiviral
cells
3.35±1.1 μM
IC50
PMID31963532 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31963532/
RECORD: Rec_0268714 VERIFIED: YES
Provenance & Taxonomy
Mesobuthus martensii [Animal]
Structure & Mods
side-chain cyclized peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
4-25, 11-33, 15-35
Bio-Activity Profile
Antimicrobial Antiviral Cytotoxic
PMID31963532 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31963532/
RECORD: Rec_0305257 VERIFIED: YES
Provenance & Taxonomy
Olivierus martensii [Animal]
Defensin
34649
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
4-25, 11-33, 15-35
Disulfide bonds between Cys4 and Cys25, Cys11 and Cys33, Cys15 and Cys35.
Bio-Activity Profile
Antiviral Anti-HCV Replication inhibition
Hepatitis C virus (HCV) | Huh7.5.1 cells
3.35±1.1 μM
IC50
Mammalian: 30 h; Yeast: >20 h; E. coli: >10 h
PaperInhibitory Activity of a Scorpion Defensin BmKDfsin3 against Hepatitis C Virus. | Cheng Y, Sun F, Li S, Gao M, Wang L, Sarhan M, Abdel-Rahman MA, Li W, Kwok HF, Wu Y, Cao Z. | Antibiotics (Basel). 2020 Jan 17;9(1):33. | DOI:10.3390/antibiotics9010033 | PMID:31963532 PMID31963532 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31963532/
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