Peptide Database

Peptide NameBeta-defensin

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Standard StatusStandard

Sequence Length94 amino acids

Chemical FormulaC483H797N125O130S9

DescriptionStandard

        MKLFLVLIILQFEVPTDTARPRKCFSNITGYCRKKCKMGEIYEMACLNGKLCCVNEDKNKKHQKAPESPLPLPQPKGKIDYVILPTITLLTIQL
    

Molecular Weight10723.84 Da

Isoelectric Point (pI)9.24

Net Charge (pH 7.0)6.53

Net Charge (pH 7.4) 6.14

Charge Density (pH 7.0) 0.0695

GRAVY Index-0.11

Hydrophobic Moment 0.50

Boman Index0.01

Instability Index49.88

Aliphatic Index 98.51

Aromaticity 0.0638

Extinction Coeff. Reduced 4470.00

Extinction Coeff. Oxidized 4845.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 4091.57

LogP -30.04

H-bond Donors 142.0

H-bond Acceptors 147.0

Rotatable Bonds 361.0

Heavy Atoms 747.0

Ring Count 15.0

Amide Bonds 101.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0056671 VERIFIED: NO

Provenance & Taxonomy

OrganismCanis lupus familiaris [Animal]

FamilyDefensin

Tax ID9615

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Defensin Non-hemolytic Non-ribosomal

MethodQualitative functional evidence

PaperCross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract PMID16033865 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16033865/; https://www.uniprot.org/uniprotkb/Q30KS6/entry; https://bblserver.org.in/ampdb/