Peptide Database

Peptide NameBactericidal permeability-increasing protein

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length276 amino acids

Chemical FormulaC1357H2132N360O373S13

DescriptionStandard

        FSKVCDEVRSSVSTKLQPFLHTLPVTANIDKVAGIDYSLVGPPVATDSSVDLALKGEFFSITHRSPAPFSPPTMALPEAHDRMLYFGVSTYFFNTAGLVYYTAGALTYAITDDMIPKDIQLRLNTTSMLKLLYPNMAMKLRVSPSSAPALAITPEMLSLQPLVDVQAFAILPNSTLAPLFIIGVVRHRPWVFPLGLCWMALTPLEGAGSSLGNPPKPPCHVRLRGFGDMERLPRPWPGLSRAPSGQGGPGPSHLRAGDLQVRLLRWTPCGAALDGR
    

Molecular Weight29874.48 Da

Isoelectric Point (pI)9.12

Net Charge (pH 7.0)5.26

Net Charge (pH 7.4) 4.65

Charge Density (pH 7.0) 0.0191

GRAVY Index0.11

Hydrophobic Moment 0.76

Boman Index0.15

Instability Index49.47

Aliphatic Index 92.61

Aromaticity 0.0833

Extinction Coeff. Reduced 32430.00

Extinction Coeff. Oxidized 32680.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0291489 VERIFIED: NO

Provenance & Taxonomy

OrganismVaranus komodoensis [Animal]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic Non-ribosomal

TargetGram-negative bacteria

MethodQualitative functional evidence