Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length471 amino acids

Chemical FormulaC2312H3662N576O688S17

DescriptionStandard

        MLLSVTVVLSLLSCVCGENPAVQVVLTNKGLQYGKHAAADWIQERLSTITFPDITGSVHIVFGDVDYTLTGITIVKCDLPEPSVEFLQNPPGFKTTISDLSIAITGGWRTHFGLINDGGTFDMAIFNVDVTSVVQLGKEADGHLSVSSISCDAQVGDVDIEFHGGASFIFQPFVEHFKGRIRDEIQKRLCPGVEENIESFENLLHVMNVSVDVNEVLSLALPLTDIPIIGASSMNVGLKGEFYNIKAPVEPPFEAQPFTMPDKPSYMLSVGMSDFTLNSASYAYFSAKLLQLLINDSMIPAISPVHLNTTSLGKFIPKLAEMYPDMLMSVLVYAQEAPKFSIQPDAVNVTIKAVAKASVILPNGTQIPVFTINVDSKFSSELWIDDGKLKGSVKMDNLTLTLASSEVGTFKTDSLEFLARKGGEIVLIRVNQKLGEGFLVLGTKHAQLVNSVLKKEKGFILISSDVQVSLT
    

Molecular Weight51080.36 Da

Isoelectric Point (pI)4.95

Net Charge (pH 7.0)-16.70

Net Charge (pH 7.4) -17.56

Charge Density (pH 7.0) -0.0355

GRAVY Index0.24

Hydrophobic Moment 0.64

Boman Index0.19

Instability Index33.39

Aliphatic Index 105.05

Aromaticity 0.0786

Extinction Coeff. Reduced 28420.00

Extinction Coeff. Oxidized 28670.00

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Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0072339 VERIFIED: NO

Provenance & Taxonomy

OrganismAstatotilapia calliptera [Bacterium]

FamilyBPI

Tax ID8154

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence

RECORD: Rec_0181802 VERIFIED: NO