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MYP_159713
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Basic Information
Unnamed
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiparasitic ▸ Anti-Leishmania ▸ Antileishmanial
Antiparasitic ▸ Antiprotozoal
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
20 amino acids
C91H164N22O22
Standard
Sequence
IIGPVLGLVGSALGGLLKKI
Physicochemical Analysis
1918.41 Da
10.00
1.76
1.55
0.0879
1.52
0.49
0.58
12.56
190.00
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
679.70
-2.78
23.0
24.0
65.0
135.0
1.0
19.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0130354 VERIFIED: YES
Provenance & Taxonomy
Amphibia [Animal]
Bombinin
8292
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PMID12878506 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12878506/
RECORD: Rec_0160924 VERIFIED: YES
Provenance & Taxonomy
Bombina variegata [Animal]
bombinin family
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
2-Ile: D-allo-isoleucine
Bio-Activity Profile
Antimicrobial bombinin family Antibacterial Host defense
PaperPDB 2AP7 structural record; NMR; chain A; residues 1-20
RECORD: Rec_0186702 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Bombinin H2
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antiparasitic Antileishmanial
Leishmania donovani MHOM/SD/00/IS-2D
11.0 μM
IC50; MTT assay
PMID16566601 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16566601/
RECORD: Rec_0233453 VERIFIED: YES
Provenance & Taxonomy
Bombina variegata [Animal]
Bombinin
Structure & Mods
ribosomal mature linear peptide [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
Amidation
Bio-Activity Profile
Antimicrobial Antifungal Antiprotozoal
PaperB.W. Gibson et al. / The Journal of Biological Chemistry 266 (1991) 23103-23111. Bombinin-like peptides with antimicrobial activity from scin secreations from Asian toad, Bombina orientalis Evidence URLhttps://www.uniprot.org/uniprotkb/P29006/entry
RECORD: Rec_0247254 VERIFIED: YES
Provenance & Taxonomy
Bombina variegata [Plant]
Bombinin
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli D21
5 μM
MIC
PMID8223491 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8223491/
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