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MYP_159713
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Basic Information
Unnamed
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiparasitic ▸ Anti-Leishmania ▸ Antileishmanial
Antiparasitic ▸ Antiprotozoal
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
20 amino acids
C91H164N22O22
Standard
Sequence
IIGPVLGLVGSALGGLLKKI
Physicochemical Analysis
1918.41 Da
10.00
1.76
1.55
0.0879
1.52
0.49
0.58
12.56
190.00
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
679.70
-2.78
23.0
24.0
65.0
135.0
1.0
19.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0090430 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antibacterial Antiparasitic Toxic Antimicrobial Hemolytic Anti-Gram-positive Cytotoxic Antileishmanial Anti-Gram-negative
PaperAPD2: the updated antimicrobial peptide database and its application in peptide design PMID18957441 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18957441/
RECORD: Rec_0103150 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Bombinin H2
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antiparasitic Antileishmanial
Leishmania pifanoi MHOM/VE/60/Ltrod (amastigote axenic)
MTT assay
PMID16566601 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16566601/
RECORD: Rec_0115922 VERIFIED: YES
Provenance & Taxonomy
Bombina variegata [Animal]
Bombinin
Structure & Mods
ribosomal mature linear peptide [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Staphylococcus aureus
4.7 μM
MIC
PaperM. Simmaco et al. / Biochimica et Biophysica Acta 1788 (2009) 1551-1555. Bombinins, antimicrobial peptides from Bombina species Evidence URLhttps://www.uniprot.org/uniprotkb/P29006/entry
RECORD: Rec_0124402 VERIFIED: YES
Provenance & Taxonomy
Bombina variegata [Animal]
Bombinin
Structure & Mods
ribosomal mature linear peptide [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Escherichia coli
4.4 μM
MIC
PaperM. Simmaco et al. / Biochimica et Biophysica Acta 1788 (2009) 1551-1555. Bombinins, antimicrobial peptides from Bombina species Evidence URLhttps://www.uniprot.org/uniprotkb/P82286/entry
RECORD: Rec_0129595 VERIFIED: YES
Provenance & Taxonomy
Bombina variegata [Animal]
Bombinin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli D21
5.0 μM
MIC
PMID8223491 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8223491/
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