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MYP_159645
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Basic Information
Dybowskin-1 (Frogs, amphibians, animals)
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibiotic activity
Antimicrobial ▸ Antifungal
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Defense peptide
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Standard
17 amino acids
C85H145N23O20S3
Standard
Sequence
FLIGMTHGLICLISRKC
Physicochemical Analysis
1905.40 Da
8.96
1.83
1.54
0.1074
1.22
0.44
0.35
24.28
137.65
0.0588
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
685.98
-3.72
27.0
26.0
64.0
131.0
2.0
16.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0320597 VERIFIED: YES
Provenance & Taxonomy
Rana dybowskii [Animal]
Brevinin
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
11-17
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Escherichia coli
52.5 μM
MIC
PaperS.S. Kim et al. / Peptides 28 (2007) 1532-1539. Purification and characterization of antimicrobial peptides from the skin secretion of Rana dybowskii Evidence URLhttps://www.uniprot.org/uniprotkb/P0C5W9/entry
RECORD: Rec_0322910 VERIFIED: YES
Provenance & Taxonomy
Rana dybowskii [Animal]
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
11-17
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Micrococcus luteus ATCC4698
12.5 μg/mL
MIC
PMID17698251 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17698251/
RECORD: Rec_0335344 VERIFIED: YES
Provenance & Taxonomy
Rana chensinensis [Animal]
brevinin
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
11-17
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Staphylococcus aureus
13.1 μM
MIC
PaperS.S. Kim et al. / Peptides 28 (2007) 1532-1539. Purification and characterization of antimicrobial peptides from the skin secretion of Rana dybowskii Evidence URLhttps://www.uniprot.org/uniprotkb/B8QZV6/entry
RECORD: Rec_0377128 VERIFIED: YES
Provenance & Taxonomy
Rana dybowskii [Animal]
Brevinin
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
11-17
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Staphylococcus aureus
13.1 μM
MIC
PaperS.S. Kim et al. / Peptides 28 (2007) 1532-1539. Purification and characterization of antimicrobial peptides from the skin secretion of Rana dybowskii Evidence URLhttps://www.uniprot.org/uniprotkb/P0C5W9/entry
RECORD: Rec_0400507 VERIFIED: YES
Provenance & Taxonomy
Rana dybowskii [Animal]
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
11-17
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Hemolytic
PMID17698251 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17698251/
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