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MYP_159645
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Basic Information
Dybowskin-1 (Frogs, amphibians, animals)
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibiotic activity
Antimicrobial ▸ Antifungal
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Defense peptide
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Standard
17 amino acids
C85H145N23O20S3
Standard
Sequence
FLIGMTHGLICLISRKC
Physicochemical Analysis
1905.40 Da
8.96
1.83
1.54
0.1074
1.22
0.44
0.35
24.28
137.65
0.0588
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
685.98
-3.72
27.0
26.0
64.0
131.0
2.0
16.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0021029 VERIFIED: YES
Provenance & Taxonomy
Rana dybowskii [Animal]
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
11-17
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Hemolytic
huamn red blood cells
PMID17698251 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17698251/
RECORD: Rec_0029707 VERIFIED: YES
Provenance & Taxonomy
Rana dybowskii [Animal]
Brevinin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Refer PubMed ID: 17698251 Micrococcus luteus
60 μg/mL
MIC
PMID17688900;17698251 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17688900/
RECORD: Rec_0031644 VERIFIED: NO
Provenance & Taxonomy
Rana dybowskii [Animal]
Frog skin active peptide (FSAP)
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Amphibian defense peptide Antibiotic Antimicrobial Non-hemolytic Non-ribosomal
Qualitative functional evidence
PMID17688900 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17688900/; https://www.uniprot.org/uniprotkb/P0C5W9/entry; https://bblserver.org.in/ampdb/
RECORD: Rec_0043838 VERIFIED: YES
Provenance & Taxonomy
Rana dybowskii [Animal]
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
11-17
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
PMID17698251 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17698251/
RECORD: Rec_0050223 VERIFIED: YES
Provenance & Taxonomy
Rana dybowskii [Animal]
Brevinin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Refer PubMed ID: 17698251 Micrococcus luteus
12.5 μg/mL
MIC
PMID17688900;17698251 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17688900/
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