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MYP_159613
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Basic Information
D-Brevinin CTcu5 (11-21)
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
21 amino acids
C103H178N28O24S2
Standard
Sequence
LIAGLAANFLPQILCKIARKC
Physicochemical Analysis
2256.82 Da
9.50
2.74
2.50
0.1304
1.07
0.74
0.29
25.84
149.05
0.0476
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
836.65
-4.60
30.0
29.0
75.0
157.0
2.0
22.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0354129 VERIFIED: YES
Provenance & Taxonomy
Clinotarsus curtipes,Odorrana andersonii,Odorrana grahami [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hemolytic
Rabbit erythrocytes (38% Hemolysis at 200 microg/ml, Human erythrocytes (40% Hemolysis at 200 microg/ml, Human embryonic kidney HEK293 cells (50% Cytotoxicity at >100 microg/ml, Human erythrocytes (37% Hemolysis at 200 microg/ml, Human erythrocytes (40.22% Hemolysis at 200 microg/ml
200 μg/mL
Hemolysis
PMID24161537;25997127;32679168 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24161537/
RECORD: Rec_0355874 VERIFIED: YES
Provenance & Taxonomy
Clinotarsus curtipes,Odorrana andersonii,Odorrana grahami [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Vibrio cholerae
15-25 μg/mL
MIC
PMID24161537;25997127;32679168 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24161537/
RECORD: Rec_0365364 VERIFIED: YES
Provenance & Taxonomy
Clinotarsus curtipes [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Escherichia coli
7 μM
MIC
RECORD: Rec_0376865 VERIFIED: YES
Provenance & Taxonomy
Clinotarsus curtipes [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
15-21
Bio-Activity Profile
Antimicrobial
V. cholerae
15 μg/mL
MIC
PaperNovel antibacterial peptides from the skin secretion of the Indian bicoloured frog Clinotarsus curtipes.
RECORD: Rec_0379322 VERIFIED: YES
Provenance & Taxonomy
Clinotarsus curtipes,Odorrana andersonii,Odorrana grahami [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Staphylococcus aureus ATCC 43300
100 μg/mL
MIC
PMID24161537;25997127;32679168 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24161537/
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