Peptide Database

Peptide NameSLAY-screened peptide P1957

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC85H139N23O33

DescriptionStandard

        TAASLSSVANSQLLSENAFT
    

Molecular Weight2011.15 Da

Isoelectric Point (pI)4.05

Net Charge (pH 7.0)-1.60

Net Charge (pH 7.4) -1.79

Charge Density (pH 7.0) -0.0799

GRAVY Index0.31

Hydrophobic Moment 0.24

Boman Index0.19

Instability Index38.39

Aliphatic Index 93.00

Aromaticity 0.0500

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 924.40

LogP -14.67

H-bond Donors 32.0

H-bond Acceptors 32.0

Rotatable Bonds 65.0

Heavy Atoms 141.0

Ring Count 1.0

Amide Bonds 22.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0104532 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/