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MYP_159473
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Basic Information
Sparamosin26-54
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Anti-biofilm ▸ Biofilm inhibition
Antimicrobial ▸ Antifungal
Standard
29 amino acids
C147H234N46O36S5
Standard
Sequence
GLGPNPCRKKCYKRDFLGRCRLNFTCMFG
Physicochemical Analysis
3382.04 Da
9.79
5.72
5.45
0.1972
-0.53
0.33
-0.21
20.76
40.34
0.1379
1490.00
1740.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1350.14
-13.16
52.0
47.0
111.0
234.0
6.0
30.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0433499 VERIFIED: YES
Provenance & Taxonomy
Scylla paramamosain [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Fungicidal
Cryptococcus neoformans CGMCC No. 2.1563
99 %
Time-kill assay (10 min)
PaperChen YC, Yang Y, Zhang C, et al. A Novel Antimicrobial Peptide Sparamosin26-54 From the Mud Crab Scylla paramamosain Showing Potent Antifungal Activity Against Cryptococcus neoformans. Front Microbiol. 2021;12:746006. DOI:10.3389/fmicb.2021.746006. PMID:34690992. PMID34690992
RECORD: Rec_0433500 VERIFIED: YES
Provenance & Taxonomy
Scylla paramamosain [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Antibiofilm
Cryptococcus neoformans biofilm
12 μM
Biofilm formation inhibition (crystal violet assay)
PaperChen YC, Yang Y, Zhang C, et al. A Novel Antimicrobial Peptide Sparamosin26-54 From the Mud Crab Scylla paramamosain Showing Potent Antifungal Activity Against Cryptococcus neoformans. Front Microbiol. 2021;12:746006. DOI:10.3389/fmicb.2021.746006. PMID:34690992. PMID34690992
RECORD: Rec_0433501 VERIFIED: YES
Provenance & Taxonomy
Scylla paramamosain [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Antibiofilm
Cryptococcus neoformans biofilm
>90 %
Biofilm formation inhibition at 48 μM (crystal violet assay)
PaperChen YC, Yang Y, Zhang C, et al. A Novel Antimicrobial Peptide Sparamosin26-54 From the Mud Crab Scylla paramamosain Showing Potent Antifungal Activity Against Cryptococcus neoformans. Front Microbiol. 2021;12:746006. DOI:10.3389/fmicb.2021.746006. PMID:34690992. PMID34690992
RECORD: Rec_0433502 VERIFIED: YES
Provenance & Taxonomy
Scylla paramamosain [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Antibiofilm
Preformed Cryptococcus neoformans biofilm
>50 %
Preformed-biofilm respiratory activity inhibition at 48 μM (resazurin assay)
PaperChen YC, Yang Y, Zhang C, et al. A Novel Antimicrobial Peptide Sparamosin26-54 From the Mud Crab Scylla paramamosain Showing Potent Antifungal Activity Against Cryptococcus neoformans. Front Microbiol. 2021;12:746006. DOI:10.3389/fmicb.2021.746006. PMID:34690992. PMID34690992
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